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Analysis of selected gene variants in athletes - runners at 400 m
Šplíchalová, Dominika ; Petr, Miroslav (advisor) ; Šteffl, Michal (referee)
Title: Analysis of selected gene variants in athletes - runners at 400 m Objectives: This work aims to find out what the genetic profile of athletes - runners at 400 meters, who are working in lactate mode, looks like. Methods: A cross-sectional investigation involved 203 East European Caucasian males and was conducted collaboratively at the FTVS UK and Józef Piłsudski University of Physical Education in Warsaw (AWF Warsaw). The athletes, after a brief warm- up, participated in a single 30-second Wingate test. DNA samples were collected non-invasively through saliva swabs. Lactate levels were measured using an invasive approach. Results: In the polymorphisms rs4646994 gene ACE was found to have a significant difference in genotypic (p = 0.001, x2 = 14.90) and allelic (p = 0.004, x2 = 8.52) frequencies between the overall athlete group and the controls. A notable difference in the ACE gene showed the comparison of the genotypes (p = 0.001, x2 = 13.66) and between the alleles (p = 0.003, x2 = 8.89) between the control group and elite athletes. The last statistically significant difference was observed among the genotypes (p = 0.03, x2 = 6.79) between the sub-elite athletes and the control group. When assessing the genotypic and allelic frequencies for the polymorphisms rs1815739 in the ACTN3 gene, we...
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